ื’ื™ืœ ื”ืžืขื‘ืจ ื”ื•ื ืชื—ื™ืœืช ื”ืžืขื‘ืจ ืœื—ื™ื“ืœื•ืŸ ื•ืกืช. ื”ื•ื ื™ื›ื•ืœ ืœื”ืชื—ื™ืœ ื‘ืืžืฆืข ืฉื ื•ืช ื”ืฉืœื•ืฉื™ื ืœื—ื™ื™ื ื•ืœื”ื™ืžืฉืš ื‘ื™ืŸ ืฉื ืชื™ื™ื ืขื“ 10 ืฉื ื™ื. ื›-85% ืžื”ื ืฉื™ื ื—ื•ื•ืช ืชืกืžื™ื ื™ื ื’ื•ืคื ื™ื™ื ื•ืจื’ืฉื™ื™ื ืฉื ื’ืจืžื™ื ืขืœ-ื™ื“ื™ ื”ืฉื™ื ื•ื™ื™ื ื”ื”ื•ืจืžื•ื ืœื™ื™ื ื”ื ืงืฉืจื™ื ืœื’ื™ืœ ื”ืžืขื‘ืจ.1 

ืœืžืจื‘ื” ื”ืžื–ืœ, ื™ืฉ ื“ื‘ืจื™ื ืจื‘ื™ื ืฉืืช ื™ื›ื•ืœื” ืœืขืฉื•ืช ื›ื“ื™ ืœื”ืจื’ื™ืฉ ื˜ื•ื‘ ื™ื•ืชืจ ื•ืœื”ื™ืฉืืจ ื‘ืจื™ืื”, ืžืคืขื™ืœื•ืช ื’ื•ืคื ื™ืช ืกื“ื™ืจื” ื•ืื›ื™ืœืช ืชื–ื•ื ื” ื ื•ื’ื“ืช ื“ืœืงืช ื•ืขื“ ืฉื™ืžื•ืฉ ื—ื›ื ื‘ืชื•ืกืคื™ื. ื”ืžืฉื™ื›ื™ ืœืงืจื•ื ื›ื“ื™ ืœืœืžื•ื“ ืขืœ ื›ืžื” ืžื”ืชื•ืกืคื™ื ื”ื˜ื•ื‘ื™ื ื‘ื™ื•ืชืจ ืœื’ื™ืœ ื”ืžืขื‘ืจ ืฉื™ื›ื•ืœื™ื ืœื”ืงืœ ืขืœ ืชืกืžื™ื ื™ ื’ื™ืœ ื”ืžืขื‘ืจ ื‘ืื•ืคืŸ ื˜ื‘ืขื™.

ืžื”ื• ื’ื™ืœ ื”ืžืขื‘ืจ? 

ื’ื™ืœ ื”ืžืขื‘ืจ ื”ื•ื ื”ืชืงื•ืคื” ืฉืžื•ื‘ื™ืœื” ืœื—ื™ื“ืœื•ืŸ ื•ืกืช, ืื– ื”ืฉื—ืœื•ืช ืžืชื—ื™ืœื•ืช ืœื—ื“ื•ืœ ืžืœืชืคืงื“ ื•ืจืžื•ืช ื”ื”ื•ืจืžื•ื ื™ื ื™ื•ืจื“ื•ืช. ืืžื ื ืจื‘ื™ื ืžืฉืชืžืฉื™ื ื‘ืžื•ื ื— "ื—ื™ื“ืœื•ืŸ ื•ืกืช" (ืžื ื•ืคืื•ื–ื”) ืœืชื™ืื•ืจ ืชืงื•ืคืช ื”ื—ื™ื™ื ืฉื‘ื” ืžื•ืคื™ืขื™ื ืชืกืžื™ื ื™ ื’ื™ืœ ื”ืžืขื‘ืจ ื›ืžื• ื’ืœื™ ื—ื•ื, ืื‘ืœ ื—ื™ื“ืœื•ืŸ ื•ืกืช ืžื•ื’ื“ืจ ื›ื ืงื•ื“ืช ื”ื–ืžืŸ ืฉื‘ื” ืœื ื”ื™ื™ืชื” ืœืื™ืฉื” ื•ืกืช ื‘ืžืฉืš 12 ื—ื•ื“ืฉื™ื ื‘ืจืฆืฃ. ืœืžืขืฉื”, ืžื—ื–ื•ืจ ื”ื•ื•ืกืช ื ืคืกืง. ื–ื” ื”ื’ื™ื•ื ื™, ื›ื™ ื”ืžื•ื ื— ื”ืœื•ืขื–ื™ "ืžื ื•ืคืื•ื–ื”" ื ื’ื–ืจ ืžื”ืžื™ืœื™ื ื”ื™ื•ื•ื ื™ื•ืช "ืคืื•ื–ื™ืก" (ื”ืคืกืงื”) ื•"ืžืŸ" (ื—ื•ื“ืฉ). 

ื‘ื›ืœ ืฉื ื”, ื‘ืขืจืš 46.5 ืžื™ืœื™ื•ืŸ ื ืฉื™ื ื‘ื›ืœ ืจื—ื‘ื™ ื”ืขื•ืœื ื•-1.3 ืžื™ืœื™ื•ืŸ ื ืฉื™ื ื‘ืืจื”"ื‘ ืžื’ื™ืขื•ืช ืœื—ื™ื“ืœื•ืŸ ื•ืกืช. ืจื•ื‘ ื”ื ืฉื™ื ื”ืืžืจื™ืงืื™ื•ืช ืžื’ื™ืขื•ืช ืœื—ื™ื“ืœื•ืŸ ื•ืกืช ื‘ื’ื™ืœ ื‘ื™ืŸ 45 ืœ-56 ืฉื ื”, ื›ืฉื”ื’ื™ืœ ื”ืžืžื•ืฆืข ื”ื•ื 51. 

ืื™ืŸ ื‘ื“ื™ืงื” ืœืื‘ื—ื•ืŸ ื—ื“-ืžืฉืžืขื™ ืฉืœ ื’ื™ืœ ื”ืžืขื‘ืจ. ืืช ื™ื›ื•ืœื” ืœืขืฉื•ืช ื‘ื“ื™ืงืช ื“ื ืœืžื“ื™ื“ืช ื”ืจืžื•ืช ืฉืœ ื”ื•ืจืžื•ืŸ ืžื’ืจื” ื”ื–ืงื™ืง (FSH) ื•ืืกื˜ืจื“ื™ื•ืœ, ืฆื•ืจื” ืฉืœ ืืกื˜ืจื•ื’ืŸ. ื ื™ืชืŸ ืœื”ืฉื™ื’ ื’ื ืขืจื›ื” ืœื‘ื“ื™ืงืช FSH ื‘ืฉืชืŸ ืฉื ืžื›ืจืช ืœืœื ืžืจืฉื. ืขื ื–ืืช, ืžืื—ืจ ืฉื‘ืžื”ืœืš ืžื—ื–ื•ืจ ื”ื•ื•ืกืช ื—ืœื™ื ืงื™ื™ืžื•ืช ืชื ื•ื“ื•ืช ืžืฉืžืขื•ืชื™ื•ืช ื‘ืจืžื•ืช ื”-FSH ื•ื”ืืกื˜ืจื•ื’ืŸ, ืงืฉื” ืœืงื‘ื•ืข ื‘ื•ื•ื“ืื•ืช ืขืœ ืกืžืš ืชื•ืฆืื•ืช ื”ื‘ื“ื™ืงื•ืช ื”ืœืœื• ืฉื”ื’ืขืช ืœื’ื™ืœ ื”ืžืขื‘ืจ. 

ืจื•ื‘ ื”ื ืฉื™ื ื™ื›ื•ืœื•ืช ืœืื‘ื—ืŸ ืืช ื’ื™ืœ ื”ืžืขื‘ืจ ื‘ืขืฆืžืŸ, ื‘ื’ืœืœ ื”ืชืกืžื™ื ื™ื ื”ื ืคื•ืฆื™ื ื•ืื™-ืกื“ื™ืจื•ืช ื‘ื•ื•ืกืช. ื ืฉื™ื ืื—ืจื•ืช ืžืชื™ื™ืขืฆื•ืช ืขื ืจื•ืคืื™ื ืœื’ื‘ื™ ื”ืชืกืžื™ื ื™ื. ื—ืฉื•ื‘ ืœืฉืชืฃ ืคืขื•ืœื” ืขื ืจื•ืคืื™ื ืฉืžื‘ื™ื ื™ื ืืช ื’ื™ืœ ื”ืžืขื‘ืจ ื•ืžื•ื›ื ื™ื ืœื”ืงืฉื™ื‘ ืœืš. 

ื”ืชืกืžื™ื ื™ื ื”ื ืคื•ืฆื™ื ืฉืœ ื’ื™ืœ ื”ืžืขื‘ืจ

ื›ืœ ืื—ืช ื—ื•ื•ื” ืืช ื’ื™ืœ ื”ืžืขื‘ืจ ื‘ืฆื•ืจื” ืื—ืจืช. ื”ืชืกืžื™ื ื™ื ื”ืฉื›ื™ื—ื™ื ื‘ื™ื•ืชืจ ื”ื ื•ื–ื•ืžื•ื˜ื•ืจื™ื™ื, ืชืกืžื™ื ื™ื ืฉืงืฉื•ืจื™ื ืœื”ืจื—ื‘ื” ืื• ื”ืชื›ื•ื•ืฆื•ืช ืฉืœ ื›ืœื™ ื“ื. ื‘ื™ืŸ ื”ืชืกืžื™ื ื™ื ื”ืœืœื• ื’ืœื™ ื—ื•ื ื•ื”ื–ืขื•ืช ืœื™ืœื”.  ืœืคื™ ื”ืงืจืŸ ื”ืœืื•ืžื™ืช ืœื’ื™ืœ ื”ืžืขื‘ืจ ื‘ืืจื”"ื‘, 75% ืžื”ื ืฉื™ื ื—ื•ื•ืช ื’ืœื™ ื—ื•ื ื‘ืชืงื•ืคืช ื—ื™ื“ืœื•ืŸ ื•ืกืช.2 

ื‘ื™ืŸ ื”ืชืกืžื™ื ื™ื ื”ื ืคื•ืฆื™ื ืฉืœ ื’ื™ืœ ื”ืžืขื‘ืจ:3 

  • ื’ืœื™ ื—ื•ื
  • ื”ื–ืขืช ืœื™ืœื”
  • ืชื ื•ื“ื•ืช ื‘ืžืฆื‘ ื”ืจื•ื—
  • ืขืจืคื•ืœ ืžื—ืฉื‘ืชื™
  • ื ืฉื™ืจืช ืฉื™ืขืจ
  • ื‘ืขื™ื•ืช ืฉื™ื ื”
  • ื™ืจื™ื“ื” ื‘ื—ืฉืง ื”ืžื™ื ื™
  • ื“ืœืงืช ื‘ื ืจืชื™ืง
  • ื›ืื‘ื™ ืจืืฉ
  • ื“ื™ื›ืื•ืŸ
  • ื›ืื‘ื™ ืžืคืจืงื™ื
  • ืื•ืกื˜ืื•ืคื•ืจื•ื–ื™ืก
  • ืขืœื™ื™ื” ื‘ืžืฉืงืœ

ืื ืืช ืžืชืงืจื‘ืช ืœื—ื™ื“ืœื•ืŸ ื•ืกืช, ื—ืฉื•ื‘ ืœื“ืขืช ืฉื”ืกื™ื›ื•ืŸ ืœืžื—ืœื•ืช ืœื‘, ืœืื•ื‘ื“ืŸ ืžืกืช ืฉืจื™ืจ ื•ืœืื•ื‘ื“ืŸ ืžืกืช ืขืฆื ืขื•ืœื” ื›ื›ืœ ืฉืจืžื•ืช ื”ื”ื•ืจืžื•ื ื™ื ื™ื•ืจื“ื•ืช. ื”ืกื™ื‘ื” ืœื›ืš ื”ื™ื ืฉืืกื˜ืจื•ื’ืŸ ืžืกื™ื™ืข ืœื”ื’ื ื” ืขืœ ื”ืฉืจื™ืจื™ื, ื”ืขืฆืžื•ืช ื•ืžืขืจื›ืช ื”ืœื‘ ื•ื›ืœื™ ื”ื“ื. 

ืชื•ืกืคื™ื ืœื’ื™ืœ ื”ืžืขื‘ืจ

ืœืฆื“ ืื•ืจื— ื—ื™ื™ื ื‘ืจื™ื, ื ื˜ื™ืœืช ืชื•ืกืคื™ื ืœื’ื™ืœ ื”ืžืขื‘ืจ ื™ื›ื•ืœื” ืœืกื™ื™ืข ืœื”ืงืœื” ื˜ื‘ืขื™ืช ืขืœ ื”ืชืกืžื™ื ื™ื ื•ืœืฉืžื™ืจื” ืขืœ ื‘ืจื™ืื•ืช ื›ืœืœื™ืช ืžื™ื˜ื‘ื™ืช, ื›ื“ื™ ืฉืชื•ื›ืœื™ ืœื™ื”ื ื•ืช ืžื”ืขืฉื•ืจื™ื ื”ื‘ืื™ื ืฉืœ ื—ื™ื™ืš.

ืกื™ื“ืŸ

ืื—ืจื™ ื—ื™ื“ืœื•ืŸ ื”ื•ื•ืกืช, ืฆืคื™ืคื•ืช ื”ืขืฆื ื”ืžื™ื ืจืœื™ืช ืฉืœ ื ืฉื™ื ื™ื•ืจื“ืช ื‘ืžืžื•ืฆืข ื‘ืื—ื•ื– ืื—ื“ ื‘ื›ืœ ืฉื ื”.4 ืœื›ืŸ, ื—ืฉื•ื‘ ืœืžื ื•ืข ืืช ืื•ื‘ื“ืŸ ื”ืขืฆื ืฉืžืชื—ื™ืœ ื‘ื’ื™ืœ ื”ืžืขื‘ืจ. ืฆืจื™ื›ื” ืžืกืคืงืช ืฉืœ ืกื™ื“ืŸ, ื”ืžื™ื ืจืœ ื”ื ืคื•ืฅ ื‘ื™ื•ืชืจ ื‘ื’ื•ืฃ ื”ืื“ื, ื™ื›ื•ืœื” ืœืกื™ื™ืข ืœืฉืžื™ืจื” ืขืœ ืฆืคื™ืคื•ืช ื”ืขืฆื ื•ืœื”ืคื—ื™ืช ืืช ื”ืกื™ื›ื•ืŸ ืœืื•ืกื˜ืื•ืคื•ืจื•ื–ื™ืก ื•ืœืฉื‘ืจื™ื. 

ืœืคื™ ืžื—ืงืจื™ื, ื ื˜ื™ืœืช ืชื•ืกืคื™ื ื™ื›ื•ืœื” ืœืกื™ื™ืข ืœืฉื™ืžื•ืจ ื”ืขืฆื. ืžื—ืงืจ ื‘ื”ืฉืชืชืคื•ืช ื›ืžืขื˜ 1,500 ื ืฉื™ื ืœืื—ืจ ื—ื™ื“ืœื•ืŸ ื•ืกืช ืฉืงื™ื‘ืœื• ืชื•ืกืคื™ื ืขื 1,000 ืžื™ืœื™ื’ืจื ืฉืœ ืกื™ื“ืŸ ืฆื™ื˜ืจื˜ ืื• ืคืœืฆื‘ื• ืžื“ื™ ื™ื•ื, ื”ื“ื’ื™ื ืชื•ืขืœืช ืžืฉืžืขื•ืชื™ืช ืฉืœ ื ื˜ื™ืœืช ืชื•ืกืคื™ ืกื™ื“ืŸ ืขื‘ื•ืจ ืฆืคื™ืคื•ืช ื”ืขืฆื.5 

ืกื™ื“ืŸ ื’ื ืžืขื•ืจื‘ ื‘ื”ืชื›ื•ื•ืฆื•ืช ืฉืจื™ืจื™ื, ื›ื•ืœืœ ื”ืชื›ื•ื•ืฆื•ืช ืฉืจื™ืจ ื”ืœื‘. ืžืฉืžืขื•ืช ื”ื“ื‘ืจ ื”ื™ื ืฉื”ื•ื ืขืฉื•ื™ ืœืชืจื•ื ืœื‘ืจื™ืื•ืช ื”ืœื‘ ื•ื›ืœื™ ื”ื“ื.6 ืžื—ืงืจ ื‘ื”ืฉืชืชืคื•ืช ื™ื•ืชืจ ืž-34,000 ื ืฉื™ื ื”ืขืœื” ื›ื™ ืฆืจื™ื›ื” ื’ื‘ื•ื”ื” ื™ื•ืชืจ ืฉืœ ืกื™ื“ืŸ ืžืชื–ื•ื ื”, ืžืชื•ืกืคื™ื ืื• ืžืฉื™ืœื•ื‘ ืฉืœ ืชื–ื•ื ื” ื•ืชื•ืกืคื™ื ื ืงืฉืจืช ืœื™ืจื™ื“ื” ื‘ืกื™ื›ื•ืŸ ืœืชืžื•ืชื” ืžืžื—ืœื•ืช ืขื•ืจืงื™ื ื›ืœื™ืœื™ื™ื ืืฆืœ ื ืฉื™ื ืœืื—ืจ ื—ื™ื“ืœื•ืŸ ื•ืกืช.7 

ืื—ืจื™ ื’ื™ืœ 50, ื”ืฆืจื™ื›ื” ื”ื™ื•ืžื™ืช ื”ืžื•ืžืœืฆืช ืฉืœ ืกื™ื“ืŸ ืขื•ืœื” ื‘-200 ืžื™ืœื™ื’ืจื ื‘ื™ื•ื, ืž-1,000 ืœ-1,200 ืžื™ืœื™ื’ืจื. ื‘ื™ืŸ ื”ืžืงื•ืจื•ืช ื”ืชื–ื•ื ืชื™ื™ื ืฉืœ ืกื™ื“ืŸ ืžื•ืฆืจื™ ื—ืœื‘, ื“ื’ื™ื ืขื ืขืฆืžื•ืช, ื›ืžื• ืฉื™ืžื•ืจื™ ืกืจื“ื™ื ื™ื ืื•ืกืœืžื•ืŸ, ื˜ื•ืคื• ื•ืคื•ืœื™ ืกื•ื™ื”, ื™ืจืงื•ืช ื™ืจื•ืงื™ื ืžืกื•ื™ืžื™ื ื›ืžื• ืงื™ื™ืœ ื•ื‘ืจื•ืงื•ืœื™ ื•ื’ื ืžื–ื•ื ื•ืช ืฉืžื•ืขืฉืจื™ื ื‘ืกื™ื“ืŸ. 

ื ื™ืชืŸ ืœื”ืฉื™ื’ ืชื•ืกืคื™ื ืขื ืกื™ื“ืŸ ื‘ืœื‘ื“ ืื• ืขื ืกื™ื“ืŸ ื‘ืฉื™ืœื•ื‘ ืขื ื•ื™ื˜ืžื™ืŸ D ืื• ืžื™ื ืจืœื™ื ืื—ืจื™ื, ื›ืžื• ืื‘ืฅ ื•ืžื’ื ื–ื™ื•ื. ื™ืฉื ื ื’ื ืžื•ืœื˜ื™-ื•ื™ื˜ืžื™ื ื™ื ืขื ื•ื™ื˜ืžื™ื ื™ื ื•ืžื™ื ืจืœื™ื ืžืจื•ื‘ื™ื, ื›ื•ืœืœ ืกื™ื“ืŸ. ืฉืชื™ ื”ืฆื•ืจื•ืช ื”ืขื™ืงืจื™ื•ืช ืฉืœ ืกื™ื“ืŸ ื‘ืชื•ืกืคื™ื ื”ืŸ ืกื™ื“ืŸ ืคื—ืžืชื™ ื•ืกื™ื“ืŸ ืฆื™ื˜ืจื˜. ื™ืฉ ืœืงื—ืช ืกื™ื“ืŸ ืคื—ืžืชื™ ืขื ืื•ื›ืœ. ืกื™ื“ืŸ ืฆื™ื˜ืจื˜ ืžืฉืžืฉ ื›ืžืจื›ื™ื‘ ืฉืœ ืชื›ืฉื™ืจื™ื ืกื•ืชืจื™ ื—ื•ืžืฆื” ืฉื ืžื›ืจื™ื ืœืœื ืžืจืฉื, ื•ื ื™ืชืŸ ืœืงื—ืช ืื•ืชื• ืขืœ ื‘ื˜ืŸ ืจื™ืงื”. ื”ื’ื•ืฃ ื™ื›ื•ืœ ืœื ืฆืœ ืจืง ื›ืžื•ืช ืžื•ื’ื‘ืœืช ืฉืœ ืกื™ื“ืŸ ื‘ื›ืœ ืคืขื. ืœื›ืŸ, ื›ื“ืื™ ืœืคืฆืœ ืืช ืžื™ื ื•ืŸ ื”ืกื™ื“ืŸ ื”ื™ื•ืžื™ ื•ืœื™ื˜ื•ืœ ื—ืœืง ืžืžื ื• ื‘ืœื™ืœื”. ื”ืœื™ืœื” ื”ื•ื ื”ื–ืžืŸ ื”ื˜ื•ื‘ ื‘ื™ื•ืชืจ ืœืกืคื™ื’ืช ืขืฆื.

ืžื’ื ื–ื™ื•ื

ืžื’ื ื–ื™ื•ื ืžืขื•ืจื‘ ื‘ืชื’ื•ื‘ื•ืช ื‘ื™ื•ื›ื™ืžื™ื•ืช ืจื‘ื•ืช ื•ืžืขื ื™ืง ืชืžื™ื›ื” ืœื‘ืจื™ืื•ืช ื”ืขืฆื ื•ื”ืœื‘, ืœืžืขืจื›ืช ื”ื”ื•ืจืžื•ื ืœื™ืช ืœืžืขืจื›ืช ื”ืขืฆื‘ื™ื. ื”ืžื™ื ืจืœ ื”ื—ื™ื•ื ื™ ื”ื–ื” ื™ื›ื•ืœ ืœืกื™ื™ืข ืœื”ืงืœื” ืขืœ ืชืกืžื™ื ื™ื ืจื‘ื™ื ืฉืœ ื’ื™ืœ ื”ืžืขื‘ืจ ื•ืขืœ ื‘ืขื™ื•ืช ื‘ืจื™ืื•ืช ืคื•ื˜ื ืฆื™ืืœื™ื•ืช, ื›ื•ืœืœ: 

  • ื›ืื‘ื™ ืžืคืจืงื™ื 
  • ื’ืœื™ ื—ื•ื
  • ืขืœื™ื™ื” ื‘ืžืฉืงืœ
  • ืžืฆื‘ ืจื•ื— ื™ืจื•ื“ 
  • ืื•ืกื˜ืื•ืคื•ืจื•ื–ื™ืก 
  • ืžื—ืœื•ืช ืœื‘
  • ื ื“ื•ื“ื™ ืฉื™ื ื” 

ืกื•ื‘ืœืช ืžื”ืคืจืขื•ืช ืฉื™ื ื”? ืžื’ื ื–ื™ื•ื ื™ื›ื•ืœ ืœืกื™ื™ืข ืœื•ื•ื™ืกื•ืช ื”ืฉืขื•ืŸ ื”ื‘ื™ื•ืœื•ื’ื™ ื•ืœืขื–ื•ืจ ืœืš ืœื”ื™ืจื’ืข. ื ื™ืกื•ื™ ืจืคื•ืื™ ืืงืจืื™ ืื—ื“ ืžืฆื ื›ื™ ื ื˜ื™ืœืช ืชื•ืกืฃ ืขื 500 ืžื™ืœื™ื’ืจื ืžื’ื ื–ื™ื•ื ืžื“ื™ ืขืจื‘ ื‘ืžืฉืš ืฉืžื•ื ื” ืฉื‘ื•ืขื•ืช ื”ื‘ื™ืื” ืœืฉื™ืคื•ืจ ืžืฉืžืขื•ืชื™ ื‘ื–ืžืŸ ื•ื‘ืื™ื›ื•ืช ื”ืฉื™ื ื” ืืฆืœ ืงืฉื™ืฉื™ื.8 

ืžื’ื ื–ื™ื•ื ื’ื ืขืฉื•ื™ ืœืชืจื•ื ืœืฉื™ืคื•ืจ ื”ื‘ืจื™ืื•ืช ื”ื ืคืฉื™ืช, ื‘ื’ืœืœ ืžืขื•ืจื‘ื•ืชื• ื‘ืชื’ื•ื‘ืช ื”ืกื˜ืจืก, ื‘ื•ื•ื™ืกื•ืช ืžืฆื‘ ื”ืจื•ื— ื•ื‘ืคืขื™ืœื•ืช ื”ืžื•ื—. ืžืกืคืจ ืžื—ืงืจื™ื ืงืฉืจื• ืฆืจื™ื›ื” ืชื–ื•ื ืชื™ืช ื ืžื•ื›ื” ืฉืœ ืžื’ื ื–ื™ื•ื ื•ืจืžื•ืช ืžื’ื ื–ื™ื•ื ื ืžื•ื›ื•ืช ื‘ื“ื ืœืฉื™ืขื•ืจื™ ื“ื™ื›ืื•ืŸ ื’ื‘ื•ื”ื™ื ื™ื•ืชืจ.9 

ืืกื˜ืจื•ื’ืŸ ืžืคื—ื™ืช ื“ืœืงืช ื•ืžืกื›ืš ืืช ื”ืžืคืจืงื™ื. ืœื›ืŸ, ื™ืจื™ื“ื” ื‘ืจืžื•ืช ื”ืืกื˜ืจื•ื’ืŸ ื‘ื’ื™ืœ ื”ืžืขื‘ืจ ืขืœื•ืœื” ืœื”ื—ืžื™ืจ ื›ืื‘ื™ื. ื—ื•ืงืจื™ื ืžืืžื™ื ื™ื ื›ื™ ื”ื™ืจื™ื“ื” ื‘ืืกื˜ืจื•ื’ืŸ ืขืœื•ืœื” ืœื’ืจื•ื ืœื“ืœืงืช ืขืœ-ื™ื“ื™ ื”ืคื—ืชืช ืจืžืช ื”ืžื’ื ื–ื™ื•ื ื‘ืชืื™ ื”ืขืฆื‘. ืœื›ืŸ, ื”ื’ื“ืœืช ืฆืจื™ื›ืช ื”ืžื’ื ื–ื™ื•ื ืขืฉื•ื™ื” ืœืกื™ื™ืข ืœื”ืงืœื” ืขืœ ื›ืื‘ื™ื. ืžื—ืงืจ ื‘ื‘ืขืœื™ ื—ื™ื™ื ื”ืจืื” ื›ื™ ื ื˜ื™ืœืช ืชื•ืกืคื™ ืžื’ื ื–ื™ื•ื ืžื ืขื” ืื• ื”ืคื™ื’ื” ื›ืื‘ื™ื ื›ืจื•ื ื™ื™ื, ื“ืคื•ืกื™ ื”ืชื ื”ื’ื•ืช ื“ื™ื›ืื•ื ื™ื™ื ื•ืœื™ืงื•ื™ื™ ื–ื™ื›ืจื•ืŸ ืืฆืœ ื ืงื‘ื•ืช ืขื›ื‘ืจ ืžื‘ื•ื’ืจื•ืช ืื• ืœืœื ืฉื—ืœื•ืช.10 

ื‘ื“ื•ืžื” ืœืกื™ื“ืŸ ื•ืœื•ื•ื™ื˜ืžื™ืŸ D, ื’ื ืžื’ื ื–ื™ื•ื ื—ื™ื•ื ื™ ืœื‘ืจื™ืื•ืช ื”ืขืฆื. ื”ื•ื ืžืฉืคื™ืข ืขืœ ื”ืขืฆื ื‘ืื•ืคืŸ ื™ืฉื™ืจ, ื‘ื’ืœืœ ื”ืฉืคืขืชื• ืขืœ ื™ืฆื™ืจืช ืชืื™ ืขืฆื, ื•ื’ื ื‘ืื•ืคืŸ ืขืงื™ืฃ, ื‘ื’ืœืœ ื”ืฉืคืขืชื• ืขืœ ื”ืคืจืฉืช ื”ื•ืจืžื•ืŸ ื™ื•ืชืจืช ื”ืชืจื™ืก ืฉืžืžืจื™ืฅ ื‘ื ื™ื™ืช ืขืฆื ืžื—ื“ืฉ. ืœืคื™ ื”ืชื•ืฆืื•ืช ืฉืœ ืžื—ืงืจื™ื ื‘ื‘ื ื™ ืื“ื ื•ื‘ื‘ืขืœื™ ื—ื™ื™ื, ืžื—ืกื•ืจ ื‘ืžื’ื ื–ื™ื•ื ืชื•ืจื ืœื”ืชืคืชื—ื•ืช ืื•ืกื˜ืื•ืคื•ืจื•ื–ื™ืก.11 

ืœืคื™ ื”ื”ืขืจื›ื•ืช, ื›ืžื—ืฆื™ืช ืžื”ื ืฉื™ื ืœื ืžื’ื™ืขื•ืช ืœืฆืจื™ื›ืช ื”ืžื’ื ื–ื™ื•ื ื”ื™ื•ืžื™ืช ื”ืžื•ืžืœืฆืช, 310 ืขื“ 320 ืžื™ืœื™ื’ืจื ื‘ื™ื•ื. ื‘ื™ืŸ ื”ืžื–ื•ื ื•ืช ืฉืขืฉื™ืจื™ื ื‘ืžื’ื ื–ื™ื•ื ืื’ื•ื–ื™ื, ื–ืจืขื™ื ื•ืฉืขื•ืขื™ืช. ื ื™ืชืŸ ืœื”ื’ื“ื™ืœ ืืช ืฆืจื™ื›ืช ื”ืžื’ื ื–ื™ื•ื ื‘ืงืœื•ืช ืขืœ-ื™ื“ื™ ื ื˜ื™ืœืช ืชื•ืกืฃ ืขื ืžื’ื ื–ื™ื•ื ื‘ืœื‘ื“ ืื• ื‘ืฉื™ืœื•ื‘ ืขื ืžื™ื ืจืœื™ื ืื—ืจื™ื ื›ืžื• ืกื™ื“ืŸ, ืื• ืžื•ืœื˜ื™-ื•ื™ื˜ืžื™ืŸ ืฉืžื›ื™ืœ ืžื’ื ื–ื™ื•ื. 

ื™ืฉื ืŸ ืืจื‘ืข ืฆื•ืจื•ืช ืฉื•ื ื•ืช ืฉืœ ืžื’ื ื–ื™ื•ื ื”ืžืืžืจ ื”ื–ื”ื™ื›ื•ืœ ืœืขื–ื•ืจ ืœืš ืœื”ื—ืœื™ื˜ ืžื” ืฆื•ืจืช ื”ืžื’ื ื–ื™ื•ื ื”ืžืชืื™ืžื” ื‘ื™ื•ืชืจ ื‘ืฉื‘ื™ืœืš. 

ื•ื™ื˜ืžื™ืŸ D

 ื•ื™ื˜ืžื™ืŸ D โ€Žื”ื•ื ืื—ื“ ื”ื•ื•ื™ื˜ืžื™ื ื™ื ื”ื—ืฉื•ื‘ื™ื ื‘ื™ื•ืชืจ ื‘ื’ื™ืœ ื”ืžืขื‘ืจ. ื›ืžื• ื”ื•ื•ื™ื˜ืžื™ื ื™ื A, โ€ŽE โ€Žื•-K, ื•ื™ื˜ืžื™ืŸ D ื”ื•ื ื•ื™ื˜ืžื™ืŸ ืžืกื™ืก ืฉื•ืžืŸ. ื”ืขื•ืจ ืžื™ื™ืฆืจ ื•ื™ื˜ืžื™ืŸ D ืœืื—ืจ ื—ืฉื™ืคื” ืœืื•ืจ ื”ืฉืžืฉ, ื•ื ื™ืชืŸ ืœืงื‘ืœ ืื•ืชื• ื’ื ืžืชื–ื•ื ื” ืื• ืžืชื•ืกืคื™ื. ืžืขืจื™ื›ื™ื ื›ื™ ื‘ืขืจืš ืžื—ืฆื™ืช ืžื”ื ืฉื™ื ื‘ืืžืฆืข ื”ื—ื™ื™ื ืกื•ื‘ืœื•ืช ืžืžื—ืกื•ืจ ื‘ื•ื•ื™ื˜ืžื™ืŸ D.12 โ€Ž

ืžื—ืกื•ืจ ื‘ื•ื•ื™ื˜ืžื™ืŸ D ืขืœื•ืœ ืœื”ื’ื‘ื™ืจ ืืช ื”ืกื™ื›ื•ืŸ ืœื”ืชืคืชื—ื•ืช ื’ืœื™ ื—ื•ื. ืžื—ืงืจ ื‘ื”ืฉืชืชืคื•ืช 210 ื ืฉื™ื ืœืื—ืจ ื—ื™ื“ืœื•ืŸ ื•ืกืช ื”ื’ื™ืข ืœืžืกืงื ื” ื›ื™ ืงื™ื™ื ืงืฉืจ ืžืฉืžืขื•ืชื™ ื‘ื™ืŸ ืจืžื•ืช ื•ื™ื˜ืžื™ืŸ D ื ืžื•ื›ื•ืช ืœื’ืœื™ ื—ื•ื.13 

ื•ื™ื˜ืžื™ืŸ D ื—ืฉื•ื‘ ื’ื ืœื‘ืจื™ืื•ืช ื”ืขืฆื, ื›ื™ ื™ืฉ ืœื• ืชืคืงื™ื“ ืžืจื›ื–ื™ ื‘ืžื™ื ืจืœื™ื–ืฆื™ื” ืฉืœ ื”ืขืฆื. ื”ื•ื ืžืฉืคื™ืข ืขืœ ื”ืกืคื™ื’ื” ื•ื”ืฉื™ืžื•ืจ ืฉืœ ืกื™ื“ืŸ ื•ื–ืจื—ืŸ ื‘ื’ื•ืฃ. ืžื˜ื-ืื ืœื™ื–ื” ืฉืœ ืชืจื™ืกืจ ื ื™ืกื•ื™ื™ื ืืงืจืื™ื™ื ื•ืžื‘ื•ืงืจื™ื ื”ื’ื™ืขื” ืœืžืกืงื ื” ื›ื™ ื ื˜ื™ืœืช ื•ื™ื˜ืžื™ืŸ D ื‘ืžื™ื ื•ืŸ ืฉืœ 500 ืขื“ 800 ื™ื—ื™ื“ื•ืช ื‘ื™ื ืœืื•ืžื™ื•ืช (IU) ื‘ื™ื•ื ื”ื‘ื™ืื” ืœื™ืจื™ื“ื” ืฉืœ ื›-20% ื‘ืฉื™ืขื•ืจ ืฉืœ ืฉื‘ืจื™ื ื‘ืขืฆื ื”ื™ืจืš ื•ืฉืœ ืฉื‘ืจื™ื ืื—ืจื™ื ืฉืื™ื ื ื‘ืขืžื•ื“ ื”ืฉื“ืจื” ืืฆืœ ืื ืฉื™ื ืžืขืœ ื’ื™ืœ 65.14 

ืฆืจื™ื›ื” ืžืกืคืงืช ืฉืœ ื•ื™ื˜ืžื™ืŸ D ื’ื ืขืฉื•ื™ื” ืœืกื™ื™ืข ืœื”ื™ืคื˜ืจ ืžื”ืžืฉืงืœ ืฉื ืฆื‘ืจ ืขืœ ืจืงืข ื—ื™ื“ืœื•ืŸ ื•ืกืช. ื ื™ืกื•ื™ ืืงืจืื™ ื•ืžื‘ื•ืงืจ ืื—ื“ ื‘ื—ืŸ ื ืฉื™ื ืฆืขื™ืจื•ืช ืขื ืขื•ื“ืฃ ืžืฉืงืœ ื•ื”ืฉืžื ืช ื™ืชืจ ืฉื ื˜ืœื• ืชื•ืกืฃ ื•ื™ื˜ืžื™ืŸ D ื‘ืžืฉืš ืฉื™ืฉื” ืฉื‘ื•ืขื•ืช, ื•ื’ื™ืœื” ื™ืจื™ื“ื” ืžืฉืžืขื•ืชื™ืช ื‘ืžืฉืงืœ, ื‘ื”ื™ืงืฃ ื”ืžื•ืชื ื™ื™ื ื•ื‘ืžื“ื“ ืžืกืช ื”ื’ื•ืฃ ื‘ื”ืฉื•ื•ืื” ืœืงื‘ื•ืฆืช ื”ื‘ื™ืงื•ืจืช.15 

ื•ื™ื˜ืžื™ืŸ D ื’ื ืขืฉื•ื™ ืœืชืจื•ื ืœืขืœื™ื™ื” ื‘ืžืกืช ื”ืฉืจื™ืจ ื•ื‘ื›ื•ื— ื”ืฉืจื™ืจื™ื. ื›ืš, ืžื—ืงืจ ืื—ื“ ื”ื’ื™ืข ืœืžืกืงื ื” ื›ื™ ืžื—ืกื•ืจ ื‘ื•ื•ื™ื˜ืžื™ืŸ D ืžื’ื‘ื™ืจ ืืช ื”ืกื™ื›ื•ืŸ ืœืื•ื‘ื“ืŸ ื›ื•ื— ื”ืฉืจื™ืจื™ื ื‘-78%.16 

ื ื™ืชืŸ ืœื”ืฉื™ื’ ืชื•ืกืคื™ื ืขื ื•ื™ื˜ืžื™ืŸ D ื‘ืฆื•ืจืช ืืจื’ื•ืงืœืฆื™ืคืจื•ืœ (ื•ื™ื˜ืžื™ืŸ D2) ืฉืžื’ื™ืข ืžืฆืžื—ื™ื, ืื• ื‘ืฆื•ืจืช ื›ื•ืœืงืœืฆื™ืคืจื•ืœ (ื•ื™ื˜ืžื™ืŸ D3) ืฉืžื’ื™ืข ืžืžื–ื•ื ื•ืช ืžืŸ ื”ื—ื™. ืœืคื™ ืžื—ืงืจื™ื, ื•ื™ื˜ืžื™ืŸ D3 ื”ื•ื ื›ื ืจืื” ื‘ื—ื™ืจื” ื˜ื•ื‘ื” ื™ื•ืชืจ, ื›ื™ ื”ื•ื ืžื‘ื™ื ืœืขืœื™ื™ื” ืžืฉืžืขื•ืชื™ืช ื™ื•ืชืจ ื‘ืจืžื•ืช ืฉืœ ื•ื™ื˜ืžื™ืŸ D ื‘ื“ื ื•ืžืขืœื” ืื•ืชืŸ ืœืื•ืจืš ื–ืžืŸ ืจื‘ ื™ื•ืชืจ ืžืืฉืจ D2.17 โ€Ž

ื”ืฆืจื™ื›ื” ื”ื™ื•ืžื™ืช ื”ืžื•ืžืœืฆืช ืฉืœ ื•ื™ื˜ืžื™ืŸ D ืขื‘ื•ืจ ืžื‘ื•ื’ืจื™ื ืขื“ ื’ื™ืœ 70 ื”ื™ื 600 ื™ื—' ื‘ื™ื "ืœ. ื”ืžื™ื ื•ืŸ ื”ื ืกื‘ืœ ื”ื‘ื˜ื•ื— ื”ืžืจื‘ื™ ืฉืœ ื•ื™ื˜ืžื™ืŸ D ื”ื•ื 2000 ื™ื—' ื‘ื™ื "ืœ ื‘ื™ื•ื. ื ืฉื™ื ืขื ืžื—ืกื•ืจ ื‘ื•ื•ื™ื˜ืžื™ืŸ D, ืฉืื•ืชื• ื ื™ืชืŸ ืœืื‘ื—ืŸ ืขืœ-ื™ื“ื™ ื‘ื“ื™ืงืช ื“ื, ืขืฉื•ื™ื•ืช ืœื”ื–ื“ืงืง ืœืžื™ื ื•ื ื™ื ื’ื‘ื•ื”ื™ื ื™ื•ืชืจ. ืื ืืช ื—ื•ืฉืฉืช ืฉืื•ืœื™ ื™ืฉ ืœืš ืžื—ืกื•ืจ ื‘ื•ื•ื™ื˜ืžื™ืŸ D, ืคื ื™ ืœืจื•ืคื ื”ืžื˜ืคืœ ืฉืœืš ื•ืขืฉื™ ื‘ื“ื™ืงืช ื“ื ื›ื“ื™ ืœืงื‘ื•ืข ืืช ื”ืžื™ื ื•ืŸ ื”ืžืชืื™ื ืขื‘ื•ืจืš. 

ื—ื•ืžืฆื•ืช ืฉื•ืžืŸ ืื•ืžื’ื”-3

ื—ื•ืžืฆื•ืช ืฉื•ืžืŸ ืื•ืžื’ื”-3, ืื• ื‘ืงื™ืฆื•ืจ ืื•ืžื’ื”-3, ื”ืŸ ืฉื•ืžื ื™ื ื‘ืจื™ืื™ื ืฉื™ื›ื•ืœื™ื ืœืฉืžืฉ ื›ืชื•ืกืฃ ื˜ื‘ืขื™ ืžืฆื•ื™ืŸ ืœื’ื™ืœ ื”ืžืขื‘ืจ. ื—ื•ืžืฆื•ืช ืฉื•ืžืŸ ืื•ืžื’ื”-3 ืขื•ื–ืจื•ืช ืœื›ืœ ืชืื™ ื”ื’ื•ืฃ ืœืชืคืงื“ ื›ื ื“ืจืฉ ื•ืชื•ืžื›ื•ืช ื‘ื‘ืจื™ืื•ืช ื”ื ืคืฉ, ื‘ืžืขืจื›ืช ื”ืœื‘ ื•ื›ืœื™ ื”ื“ื ื•ื‘ืžืขืจื›ืช ื”ืื ื“ื•ืงืจื™ื ื™ืช. 

ืฉืœื•ืฉืช ื”ืกื•ื’ื™ื ื”ืขื™ืงืจื™ื™ื ืฉืœ ืื•ืžื’ื”-3 ื”ื: 

ืฉื™ืขื•ืจ ื”ื“ื™ื›ืื•ืŸ ื‘ืงืจื‘ ื ืฉื™ื ื‘ืืžืฆืข ื”ื—ื™ื™ื ื”ื•ื ื”ื’ื‘ื•ื” ื‘ื™ื•ืชืจ ืžื‘ื™ืŸ ื›ืœ ืงื‘ื•ืฆื•ืช ื”ื’ื™ืœ ื•ื”ืžื’ื“ืจ. ื—ื•ืžืฆื•ืช ืฉื•ืžืŸ ืื•ืžื’ื”-3 ืขืฉื•ื™ื•ืช ืœืกื™ื™ืข ื‘ื“ื™ื›ืื•ืŸ ืขืœ-ื™ื“ื™ ืฉื™ืคื•ืจ ืžื‘ื ื” ื”ืžื•ื—. ืžื—ืงืจื™ื ื‘ืงืจื‘ ื ืฉื™ื ืœืื—ืจ ื—ื™ื“ืœื•ืŸ ื•ืกืช ื”ืจืื• ื›ื™ ืงื™ื™ื ืงืฉืจ ืžืฉืžืขื•ืชื™ ื‘ื™ืŸ ืฆืจื™ื›ื” ื’ื‘ื•ื”ื” ืฉืœ ืื•ืžื’ื”-3 ืœืฉื™ืขื•ืจื™ ื“ื™ื›ืื•ืŸ ื ืžื•ื›ื™ื ื™ื•ืชืจ.18 

ื ื˜ื™ืœืช ืื•ืžื’ื”-3 ืขืฉื•ื™ื” ืœืกื™ื™ืข ื’ื ืœื”ืงืœื” ืขืœ ื’ืœื™ ื—ื•ื. ืžื—ืงืจ ื‘ื”ืฉืชืชืคื•ืช 20 ื ืฉื™ื ื‘ื’ื™ืœ ื”ืžืขื‘ืจ ื•ืœืื—ืจ ื—ื™ื“ืœื•ืŸ ื•ืกืช ืขื ื“ื™ื›ืื•ืŸ ืžื’'ื•ืจื™ ืฉืงืฉื•ืจ ืœื’ื™ืœ ื”ืžืขื‘ืจ ืžืฆื ื›ื™ ื ื˜ื™ืœืช ืฉื ื™ ื’ืจืžื™ื ืฉืœ ื—ื•ืžืฆื•ืช ืฉื•ืžืŸ ืื•ืžื’ื”-3 ื‘ื™ื•ื ื‘ืžืฉืš ืฉืžื•ื ื” ืฉื‘ื•ืขื•ืช ื”ื‘ื™ืื” ืœื™ืจื™ื“ื” ื‘ืชืกืžื™ื ื™ ื”ื“ื™ื›ืื•ืŸ ื•ื‘ื’ืœื™ ื”ื—ื•ื, ืœืœื ืชื•ืคืขื•ืช ืœื•ื•ืื™. 

ื—ื•ืžืฆื•ืช ืฉื•ืžืŸ ืื•ืžื’ื”-3 ื™ื›ื•ืœื•ืช ืœื”ืขื ื™ืง ืชืžื™ื›ื” ืœื‘ืจื™ืื•ืช ื”ืœื‘ ืขืœ-ื™ื“ื™ ื”ื•ืจื“ืช ืœื—ืฅ ื”ื“ื, ืจืžื•ืช ื”ื˜ืจื™ื’ืœื™ืฆืจื™ื“ื™ื ื•ืจืžืช ื”-LDL (ื”ื›ื•ืœืกื˜ืจื•ืœ "ื”ืจืข") ื•ื”ืขืœืืช ืจืžืช ื”-HDL (ื”ื›ื•ืœืกื˜ืจื•ืœ "ื”ื˜ื•ื‘"). ื—ื•ืžืฆื•ืช ืฉื•ืžืŸ ืื•ืžื’ื”-3 ืขืฉื•ื™ื•ืช ืœื”ืงืœ ื’ื ืขืœ ืชืกืžื™ื ื™ื ืื—ืจื™ื ืฉืœ ื’ื™ืœ ื”ืžืขื‘ืจ, ื›ื•ืœืœ ื›ืื‘ื™ ืžืคืจืงื™ื, ืื•ื‘ื“ืŸ ืขืฆื, ื›ืื‘ื™ ืžื—ื–ื•ืจ ื•ื™ื•ื‘ืฉ ื‘ื ืจืชื™ืง. ื”ืŸ ื™ื›ื•ืœื•ืช ืœืฉืžืฉ ื›ืžืฉื›ืš ื›ืื‘ื™ื ื—ื–ืง ื›ื™ ื”ืŸ ืžืคื—ื™ืชื•ืช ืืช ื”ื™ื™ืฆื•ืจ ืฉืœ ืคืจื•ืกื˜ื’ืœื ื“ื™ื ื™ื ืฉื’ื•ืจืžื™ื ืœื“ืœืงืช. 

ื’ื ืฉืžืŸ ื“ื’ื™ื, ืžืงื•ืจ ืฉืœ ืื•ืžื’ื”-3, ื™ื›ื•ืœ ืœืกื™ื™ืข ืœื™ืจื™ื“ื” ื‘ืžืฉืงืœ ืขืœ-ื™ื“ื™ ื”ืคื—ืชืช ืจืขื‘ ื•ืชื™ืื‘ื•ืŸ, ื”ื’ื‘ืจืช ื—ื™ืœื•ืฃ ื”ื—ื•ืžืจื™ื ื•ื”ืคื—ืชืช ื”ืฉื•ืžืŸ ื”ื‘ื˜ื ื™. ืžื—ืงืจ ื‘ื”ืฉืชืชืคื•ืช ื ืฉื™ื ืžื‘ื•ื’ืจื•ืช ื‘ื’ื™ืœื™ื ื‘ื™ืŸ 60 ืœ-70 ืฉื ื” ืฉื ื˜ืœื• 3 ื’ืจืžื™ื ืฉืœ ืฉืžืŸ ื“ื’ื™ื ืื• ืคืœืฆื‘ื• ืžื“ื™ ื™ื•ื ื‘ืžืฉืš 12 ืฉื‘ื•ืขื•ืช ืžืฆื ื›ื™ ื ื˜ื™ืœืช ื”ืชื•ืกืฃ ืขื ืฉืžืŸ ื“ื’ื™ื ื”ื‘ื™ืื” ืœืขืœื™ื™ื” ืžืฉืžืขื•ืชื™ืช ืฉืœ 14% ื‘ืงืฆื‘ ื—ื™ืœื•ืฃ ื”ื—ื•ืžืจื™ื ื‘ืžื ื•ื—ื”, ืœื™ืจื™ื“ื” ืฉืœ 29% ื‘ืจืžื•ืช ื”ื˜ืจื™ื’ืœื™ืฆืจื™ื“ื™ื ื•ืœืขืœื™ื™ื” ืฉืœ 4% ื‘ืžืกืช ื”ืฉืจื™ืจ.19 

ืืžื ื ืœื ื ืงื‘ืขื” ืฆืจื™ื›ื” ื™ื•ืžื™ืช ืžื•ืžืœืฆืช ืขื‘ื•ืจ ืื•ืžื’ื”-3, ืืš ืžื ื”ืœ ื”ืžื–ื•ืŸ ื•ื”ืชืจื•ืคื•ืช ื”ืืžืจื™ืงืื™ (FDA) ืงื‘ืข ื›ื™ ื”ืฆืจื™ื›ื” ื”ื”ื•ืœืžืช ืขื‘ื•ืจ ื ืฉื™ื ื‘ื•ื’ืจื•ืช ื”ื™ื 1.1 ื’ืจื ื‘ื™ื•ื. ื”-FDA ื”ื’ื™ืข ืœืžืกืงื ื” ื›ื™ ื ื˜ื™ืœืช ืชื•ืกืคื™ ืชื–ื•ื ื” ืขื EPA ื•-DHA ื‘ืžื™ื ื•ืŸ ืฉืœ ืขื“ 5 ื’ืจืžื™ื ื‘ื™ื•ื ืœื›ืœ ื”ื™ื•ืชืจ ื”ื™ื ื‘ื˜ื•ื—ื”, ืื ื ื•ื˜ืœื™ื ืืช ื”ืชื•ืกืคื™ื ืœืคื™ ื”ื”ื ื—ื™ื•ืช.20 

ืื™ื–ื•ืคืœื‘ื•ื ื™ื ืžืกื•ื™ื”

ื‘ืžื–ืจื— ื”ืจื—ื•ืง, ืฉื™ืขื•ืจ ื”ืชืกืžื™ื ื™ื ืฉืœ ื’ื™ืœ ื”ืžืขื‘ืจ ื‘ืงืจื‘ ื”ื ืฉื™ื, ื›ืžื• ื’ืœื™ ื—ื•ื, ื”ื•ื ื”ืจื‘ื” ื™ื•ืชืจ ื ืžื•ืš. ืžืขืจื™ื›ื™ื ืฉืจืง 10% ืขื“ 20% ืžื”ื ืฉื™ื ื‘ืžื–ืจื— ื”ืจื—ื•ืง, ืฉื ืกื•ื™ื” ื”ื™ื ืžืฆืจืš ืžื–ื•ืŸ ื‘ืกื™ืกื™, ืกื•ื‘ืœื•ืช ืžื’ืœื™ ื—ื•ื. 

ืกื•ื™ื” ืžื›ื™ืœื” ืื™ื–ื•ืคืœื‘ื•ื ื™ื, ืชืจื›ื•ื‘ื•ืช ื›ื™ืžื™ื•ืช ืฆืžื—ื™ื•ืช ืฉื“ื•ืžื•ืช ืœืืกื˜ืจื•ื’ืŸ ื”ืžื™ื•ืฆืจ ื‘ื’ื•ืฃ. ื”ืจื™ื›ื•ื– ื”ืžืžื•ืฆืข ืฉืœ ืื™ื–ื•ืคืœื‘ื•ืŸ ื‘ืฉื ื’ื ื™ืกื˜ืื™ืŸ ื‘ื“ื ืืฆืœ ื”ื ืฉื™ื ื‘ืžื–ืจื— ื”ืจื—ื•ืง ืฉืื•ื›ืœื•ืช ืกื•ื™ื” ื‘ืื•ืคืŸ ืงื‘ื•ืข ื’ื‘ื•ื” ื™ื•ืชืจ ื‘ืขืจืš ืคื™ 12 ืžืืฉืจ ืืฆืœ ื”ื ืฉื™ื ื‘ืืจืฆื•ืช ื”ื‘ืจื™ืช.  

ืžื—ืงืจ ืื—ื“ ื‘ื”ืฉืชืชืคื•ืช 100 ื ืฉื™ื ื‘ื’ื™ืœ ื”ืžืขื‘ืจ ื•ืœืื—ืจ ื—ื™ื“ืœื•ืŸ ื•ืกืช ื”ื“ื’ื™ื ื™ืจื™ื“ื” ื‘ืขืœืช ืžืฉืžืขื•ืช ืกื˜ื˜ื™ืกื˜ื™ืช ื‘ื’ืœื™ ื—ื•ื, ื‘ืื™-ื ื•ื—ื•ืช ื‘ืœื‘, ื‘ืื™-ื ื•ื—ื•ืช ื‘ืžืคืจืงื™ื ื•ื‘ืฉืจื™ืจื™ื ื•ื‘ื‘ืขื™ื•ืช ืฉื™ื ื” ืื—ืจื™ ื ื˜ื™ืœืช ืชื•ืกืฃ ืขื ืื™ื–ื•ืคืœื‘ื•ื ื™ื ืžืกื•ื™ื” ื‘ืžืฉืš 12 ืฉื‘ื•ืขื•ืช. ื”ืชื•ืฆืื•ืช ื”ื™ื• ื—ื–ืงื•ืช ื™ื•ืชืจ ื‘ืงืจื‘ ื”ื ืฉื™ื ื‘ื’ื™ืœ ื”ืžืขื‘ืจ.21

ืžื—ืงืจื™ื ื ื•ืกืคื™ื ืžืฆืื• ืฉืื™ื–ื•ืคืœื‘ื•ื ื™ื ืžืกื•ื™ื” ืขืฉื•ื™ื™ื ื’ื ืœื”ื’ื“ื™ืœ ืืช ื”ืฆืคื™ืคื•ืช ื”ืžื™ื ืจืœื™ืช ืฉืœ ื”ืขืฆื, ืœื”ืคื—ื™ืช ืืช ื”ืกื™ื›ื•ืŸ ืœืžื—ืœื•ืช ืœื‘ ืขืœ-ื™ื“ื™ ื”ื•ืจื“ืช ืจืžื•ืช ื”-LDL, ื”ื›ื•ืœืกื˜ืจื•ืœ "ื”ืจืข", ื•ืœื”ืงืœ ืขืœ ืชืกืžื™ื ื™ ื“ืœืงืช ืžืคืจืงื™ื ื ื™ื•ื•ื ื™ืช.

ืกื™ื‘ื™ื ืชื–ื•ื ืชื™ื™ื

ืกื™ื‘ื™ื ืชื–ื•ื ืชื™ื™ื, ื—ืœืงื™ ื”ืฆืžื—ื™ื ืฉื”ื’ื•ืฃ ืฉืœื ื• ืœื ืžืกื•ื’ืœ ืœืขื›ืœ, ื™ื›ื•ืœื™ื ืœืกื™ื™ืข ืœื”ื•ืจื“ืช ืจืžื•ืช ื”ื›ื•ืœืกื˜ืจื•ืœ, ืœืื™ื–ื•ืŸ ืจืžื•ืช ื”ืกื•ื›ืจ ื‘ื“ื, ืœืฉืžื™ืจื” ืขืœ ืžืฉืงืœ ื‘ืจื™ื, ืœืฉืœื™ื˜ื” ื‘ืชื™ืื‘ื•ืŸ, ืœื”ืคื—ืชืช ื“ื™ื›ืื•ืŸ ื•ืœื”ืงืœื” ืขืœ ื’ืœื™ ื—ื•ื. 

ื‘ืžื”ืœืš ื’ื™ืœ ื”ืžืขื‘ืจ ืขืœื•ืœื” ืœื”ืชืคืชื— ืขืฆื™ืจื•ืช, ื›ื™ ื”ืฉื™ื ื•ื™ื™ื ื‘ืจืžื•ืช ื”ื”ื•ืจืžื•ื ื™ื ื™ื›ื•ืœื™ื ืœื”ืื˜ ืืช ืงืฆื‘ ืžืขื‘ืจ ื”ืžื–ื•ืŸ ื‘ืžืขื™. ืกื™ื‘ื™ื ืขื•ื–ืจื™ื ืœืฉืžื•ืจ ืขืœ ื™ืฆื™ืื•ืช ืกื“ื™ืจื•ืช.

ืกื™ื‘ื™ื ื’ื ืžืฉืžืฉื™ื ื‘ืชื•ืจ ืคืจื”-ื‘ื™ื•ื˜ื™ืงื”. ืกื™ื‘ื™ื ืคืจื”-ื‘ื™ื•ื˜ื™ื™ื ืžื–ื™ื ื™ื ืืช ื”ืžื™ืงืจื•ืื•ืจื’ื ื™ื–ืžื™ื ื”ื—ื™ื™ื ื‘ืžืขืจื›ืช ื”ืขื™ื›ื•ืœ, ืžื” ืฉืชื•ืจื ืœืžื™ืงืจื•ื‘ื™ื•ื ื‘ืจื™ื ื™ื•ืชืจ. ื”ืžื™ืงืจื•ื‘ื™ื•ื ื”ื•ื ื”ืžืขืจื›ืช ื”ืืงื•ืœื•ื’ื™ืช ืฉืœ ื”ืžื™ืงืจื•ืื•ืจื’ื ื™ื–ืžื™ื ื”ื—ื™ื™ื ื‘ืžืขืจื›ืช ื”ืขื™ื›ื•ืœ. ื–ื” ื—ืฉื•ื‘ ืžืคื ื™ ืฉื™ืฉ ืœืืกื˜ืจื•ื’ืŸ ืชืคืงื™ื“ ื—ื™ื•ื‘ื™ ื‘ื•ื•ื™ืกื•ืช ืฉืœ ืžื™ืงืจื•ื‘ื™ื•ื ื”ืžืขื™. ื™ืจื™ื“ื” ื‘ืจืžื•ืช ื”ืืกื˜ืจื•ื’ืŸ ืžื‘ื™ืื” ื’ื ืœื™ืจื™ื“ื” ื‘ืžื’ื•ื•ืŸ ื”ืžื™ืงืจื•ืื•ืจื’ื ื™ื–ืžื™ื. ืฆืจื™ื›ืช ืกื™ื‘ื™ื ื’ื‘ื•ื”ื” ื™ื•ืชืจ ื™ื›ื•ืœื” ืœื”ื’ื“ื™ืœ ืืช ืžื’ื•ื•ืŸ ื”ื—ื™ื™ื“ืงื™ื ื•ืืช ืžืกืคืจื, ืžื” ืฉื™ืขื–ื•ืจ ืœืฉืžื•ืจ ืขืœ ื‘ืจื™ืื•ืช ื”ืžืขื™. 

ื›ื›ืœ ืฉืจืžืช ื”ื•ืจืžื•ื ื™ ื”ืžื™ืŸ ื™ื•ืจื“ืช, ื”ืชื ื’ื•ื“ืช ืœืื™ื ืกื•ืœื™ืŸ ื‘ืชืื™ ื”ื’ื•ืฃ ืขืœื•ืœื” ืœืขืœื•ืช. ื›ืชื•ืฆืื” ืžื›ืš, ื ืฉื™ื ื™ื›ื•ืœื•ืช ืœืกื‘ื•ืœ ืžืขืœื™ื•ืช ื—ื“ื•ืช ื‘ืจืžื•ืช ื”ืกื•ื›ืจ ื‘ื“ื, ืžื” ืฉืขืœื•ืœ ืœื”ื•ื‘ื™ืœ ืœื’ืœื™ ื—ื•ื. ืกื™ื‘ื™ื ืžืื˜ื™ื ืืช ื”ืขื™ื›ื•ืœ ื•ืขื•ื–ืจื™ื ืœื™ื™ืฆื‘ ืืช ืจืžื•ืช ื”ืกื•ื›ืจ ื‘ื“ื ื•ืœืžื ื•ืข ื’ืœื™ ื—ื•ื. 

ื‘ืื•ืคืŸ ืžืคืชื™ืข, ืกื™ื‘ื™ื ื’ื ืขืฉื•ื™ื™ื ืœืชืจื•ื ืœื”ืคื—ืชืช ื“ื™ื›ืื•ืŸ. ืžื—ืงืจ ื‘ื”ืฉืชืชืคื•ืช 3,054 ื ืฉื™ื ื‘ื’ื™ืœ ื”ืžืขื‘ืจ ืžืฆื ืงืฉืจ ื”ืคื•ืš ื‘ื™ืŸ ืฆืจื™ื›ืช ืกื™ื‘ื™ื ืชื–ื•ื ืชื™ื™ื ืœืชืกืžื™ื ื™ ื“ื™ื›ืื•ืŸ. ื›ื›ืœ ืฉื”ื ืฉื™ื ืื›ืœื• ื™ื•ืชืจ ืกื™ื‘ื™ื, ื›ืš ื”ืกื™ื›ื•ื™ ืฉืœื”ืŸ ืœืคืชื— ืชืกืžื™ื ื™ ื“ื™ื›ืื•ืŸ ื”ื™ื” ื ืžื•ืš ื™ื•ืชืจ.22 

ื–ื”ื• ืคืขืจ ืขืฆื•ื ืœื˜ื•ื‘ืช ืฆืจื™ื›ืช ืกื™ื‘ื™ื! ืจืง ืื—ื“ ืžื›ืœ 20 ืื ืฉื™ื ืžื’ื™ืข ืœืฆืจื™ื›ืช ื”ืกื™ื‘ื™ื ื”ื™ื•ืžื™ืช ื”ืžื•ืžืœืฆืช, 25 ื’ืจื ืœื ืฉื™ื ื•-38 ื’ืจื ืœื’ื‘ืจื™ื. ื‘ื™ืŸ ื”ืžื–ื•ื ื•ืช ืฉืขืฉื™ืจื™ื ื‘ืกื™ื‘ื™ื ืฉืขื•ืขื™ืช, ืคื™ืจื•ืช, ื™ืจืงื•ืช, ื“ื’ื ื™ื ืžืœืื™ื, ืื’ื•ื–ื™ื ื•ื–ืจืขื™ื. 

ืื ื”ืชื–ื•ื ื” ืฉืœืš ื“ืœื” ื‘ืกื™ื‘ื™ื, ืชื•ืกืฃ ืชื–ื•ื ื” ื™ื›ื•ืœ ืœืขื–ื•ืจ ืœืš ืœื”ื’ื“ื™ืœ ืืช ืฆืจื™ื›ืช ื”ืกื™ื‘ื™ื. ืงื™ื™ื ืžื’ื•ื•ืŸ ืจื—ื‘ ืฉืœ ืชื•ืกืคื™ ืกื™ื‘ื™ื, ื›ื•ืœืœ ืื‘ืงื•ืช, ืกื•ื›ืจื™ื•ืช ื’ื•ืžื™ ื•ื›ืžื•ืกื•ืช. ื›ื“ืื™ ืœื”ืชื—ื™ืœ ื ื˜ื™ืœืช ืกื™ื‘ื™ื ื‘ืงืฆื‘ ืื™ื˜ื™, ื›ื“ื™ ืฉื’ื•ืคืš ื™ื•ื›ืœ ืœื”ืชืจื’ืœ ืœื–ื”, ื‘ืžื™ื•ื—ื“ ืื ืืช ืกื•ื‘ืœืช ืžื”ืฆื˜ื‘ืจื•ืช ื’ื–ื™ื ืื• ืžื‘ื˜ืŸ ืชืคื•ื—ื”.

ืžืืงื”

ืฆืžื— ื”ืžืืงื”, ื”ื™ื“ื•ืข ื‘ืฉื ื’'ื™ื ืกื ื’ ืคืจื•ืื ื™, ื”ื•ื ืžื–ื•ืŸ-ืขืœ ืจื‘-ืขื•ืฆืžื” ืฉืขืฉื™ืจ ื‘ื•ื•ื™ื˜ืžื™ื ื™ื ื•ื‘ืžื™ื ืจืœื™ื ืจื‘ื™ื, ื›ื•ืœืœ ื•ื™ื˜ืžื™ืŸ C, ืกื™ื“ืŸ ื•ื’ื ื‘ืจื–ืœ. ื–ื” ืžืื•ืช ืฉื ื™ื ืžืฉืชืžืฉื™ื ื‘ื• ืœืฉื™ืคื•ืจ ื”ื‘ืจื™ืื•ืช, ืจืžื•ืช ื”ืื ืจื’ื™ื” ื•ืžืฆื‘ ื”ืจื•ื—. ืฆืžื— ื”ืžืืงื” ืขืฉื•ื™ ืœืขื–ื•ืจ ืœื ืฉื™ื ื‘ื’ื™ืœ ื”ืžืขื‘ืจ ืœืฉืคืจ ืืช ื”ืชืคืงื•ื“ ื”ืงื•ื’ื ื™ื˜ื™ื‘ื™, ืœื”ืคื—ื™ืช ืขื™ื™ืคื•ืช ื•ื™ื•ื‘ืฉ ื‘ื ืจืชื™ืง ื•ืœื”ืขืœื•ืช ืืช ื”ื—ืฉืง ื”ืžื™ื ื™. 

ืžื—ืงืจ ื‘ื”ืฉืชืชืคื•ืช 20 ื ืฉื™ื ื‘ืฉืœื‘ื™ื ื”ืžื•ืงื“ืžื™ื ืฉืœ ื—ื™ื“ืœื•ืŸ ื•ืกืช ืžืฆื ื›ื™ ื ื˜ื™ืœืช ืฉื ื™ ืžื™ืœื™ื’ืจืžื™ื ืฉืœ ืฉื•ืจืฉ ืžืืงื” ื”ื‘ื™ืื” ืœืขืœื™ื™ื” ืžืฉืžืขื•ืชื™ืช ื‘ืจืžื•ืช ื”ืคืจื•ื’ืกื˜ืจื•ืŸ ื•ื”ืืกื˜ืจื•ื’ืŸ ื‘ื”ืฉื•ื•ืื” ืœืงื‘ื•ืฆืช ื”ื‘ื™ืงื•ืจืช. ืžืฉืชืชืคื•ืช ื”ืžื—ืงืจ ื”ื“ื’ื™ืžื• ื’ื ื™ืจื™ื“ื” ื ื™ื›ืจืช ื‘ืชื—ื•ืฉื•ืช ืื™-ื”ื ื•ื—ื•ืช ืฉืงืฉื•ืจื•ืช ืœื—ื™ื“ืœื•ืŸ ื•ืกืช.23 ื’ื ืกืงื™ืจื” ืฉื™ื˜ืชื™ืช ืฉืœ ืฉื™ืžื•ืฉ ื‘ืžืืงื” ืœื˜ื™ืคื•ืœ ื‘ืชืกืžื™ื ื™ ื’ื™ืœ ื”ืžืขื‘ืจ ืžืขื™ื“ื” ืขืœ ื”ืฉืคืขื” ืžื•ืขื™ืœื” ืฉืœ ืžืืงื”.24 

ื ื™ืชืŸ ื‘ืงืœื•ืช ืœื”ื•ืกื™ืฃ ืืช ืฆืžื— ื”ืžืืงื” ืœืชื–ื•ื ื”. ืืคืฉืจ ืœื”ืฉื™ื’ ืืช ืžื–ื•ืŸ-ื”ืขืœ ื”ื–ื” ื‘ืฆื•ืจืช ืื‘ืงื”, ืฉืื•ืชื” ื ื™ืชืŸ ืœื”ื•ืกื™ืฃ ืœืกืžื•ืช'ื™ ืื• ืœื™ื•ื’ื•ืจื˜, ื‘ืฆื•ืจืช ื›ืžื•ืกื•ืช ืื• ื‘ืฆื•ืจื” ืฉืœ ื—ืœื™ื˜ื”.

ืžืœื˜ื•ื ื™ืŸ

ืžืœื˜ื•ื ื™ืŸ ื”ื•ื ื”ื•ืจืžื•ืŸ ืฉืขื•ื–ืจ ืœื•ื•ืกืช ืืช ืžื—ื–ื•ืจ ื”ืขืจื•ืช ื•ื”ืฉื™ื ื”, ืื• ื”ืฉืขื•ืŸ ื”ื‘ื™ื•ืœื•ื’ื™. ื”ื•ื ืงื™ื™ื ื’ื ื‘ืฆื•ืจื” ืฉืœ ืชื•ืกืฃ ืชื–ื•ื ื” ื‘ื˜ื•ื— ืœืฉื™ืžื•ืฉ ืฉืžืฉืชืžืฉื™ื ื‘ื• ืœืฉื™ืคื•ืจ ื”ืฉื™ื ื”. ืžืœื˜ื•ื ื™ืŸ ืžื•ืคืจืฉ ืขืœ-ื™ื“ื™ ื‘ืœื•ื˜ืช ื”ืืฆื˜ืจื•ื‘ืœ ื‘ืœื™ืœื”, ื‘ืฉืขื•ืช ื”ื—ืฉื™ื›ื”. ื‘ื“ื•ืžื” ืœื”ื•ืจืžื•ื ื™ ื”ืžื™ืŸ, ื’ื ืจืžื•ืช ื”ืžืœื˜ื•ื ื™ืŸ ื™ื•ืจื“ื•ืช ืขื ื”ื’ื™ืœ, ื‘ืžื™ื•ื—ื“ ื‘ื’ื™ืœ ื”ืžืขื‘ืจ. 

ืกืงื™ืจืช ื”ื”ืฉืคืขื” ืฉืœ ืžืœื˜ื•ื ื™ืŸ ืขืœ ื‘ืจื™ืื•ืชืŸ ืฉืœ ื ืฉื™ื ื‘ื’ื™ืœ ื”ืžืขื‘ืจ ืžืฆืื” ื›ื™ ืžื™ื ื•ื ื™ื ืฉืœ ื™ื•ืชืจ ืž-3 ืžื™ืœื™ื’ืจืžื™ื ื‘ื™ื•ื ื”ื‘ื™ืื• ืœืฉื™ืคื•ืจ ื‘ืชืกืžื™ื ื™ื ื”ื ืคื•ืฆื™ื ืฉืœ ื’ื™ืœ ื”ืžืขื‘ืจ ื›ืžื• ื’ืœื™ ื—ื•ื, ื ื“ื•ื“ื™ ืฉื™ื ื”, ืชื ื•ื“ื•ืช ื‘ืžืฆื‘ ื”ืจื•ื—, ื›ืื‘ื™ ืฉืจื™ืจื™ื ื•ืžืคืจืงื™ื ื•ื”ืคืจืขื•ืช ืžื™ื ื™ื•ืช. ืื•ืชื• ื”ืžื—ืงืจ ื”ื“ื’ื™ื ืฉื™ืคื•ืจ ื‘ืื™ื›ื•ืช ื”ืฉื™ื ื” ืืฆืœ ื ืฉื™ื ืขื ื‘ืขื™ื•ืช ืฉื™ื ื” ืฉื ื˜ืœื• ืžืœื˜ื•ื ื™ืŸ.25 

ืžืœื˜ื•ื ื™ืŸ ื’ื ืขืฉื•ื™ ืœื”ืฉืคื™ืข ืœื˜ื•ื‘ื” ืขืœ ืฆืคื™ืคื•ืช ื•ื—ื•ื–ืง ื”ืขืฆื. ืžื—ืงืจ ืื—ื“ ื‘ื”ืฉืชืชืคื•ืช ื ืฉื™ื ื‘ื’ื™ืœ ื”ืžืขื‘ืจ ืฉื ื˜ืœื• 3 ืžื™ืœื™ื’ืจืžื™ื ืฉืœ ืžืœื˜ื•ื ื™ืŸ ืžื“ื™ ืœื™ืœื” ื‘ืžืฉืš ืฉื™ืฉื” ื—ื•ื“ืฉื™ื ืžืฆื ื›ื™ ืชื•ืกืฃ ื”ืžืœื˜ื•ื ื™ืŸ ื ืกื‘ืœ ื”ื™ื˜ื‘, ื”ื‘ื™ื ืœืฉื™ืคื•ืจ ื‘ืชืกืžื™ื ื™ ื’ื™ืœ ื”ืžืขื‘ืจ ื•ื’ื ืขืฉื•ื™ ืœืกื™ื™ืข ืœืžื ื™ืขื” ืฉืœ ืื•ื‘ื“ืŸ ืžืกืช ืขืฆื.26 

ืงื•ื”ื•ืฉ ืฉื—ื•ืจ

ืงื•ื”ื•ืฉ ืฉื—ื•ืจ ื”ื•ื ืชื•ืกืฃ ืคื•ืคื•ืœืจื™ ืœื‘ืจื™ืื•ืช ื”ืื™ืฉื”. ื”ืฉื™ืžื•ืฉ ื‘ืงื•ื”ื•ืฉ ืฉื—ื•ืจ ื›ืฆืžื— ืžืจืคื ื”ื—ืœ ืืช ื“ืจื›ื• ื‘ืงืจื‘ ื”ืืžืจื™ืงืื™ื ื”ื™ืœื™ื“ื™ื. ืงื•ื”ื•ืฉ ืฉื—ื•ืจ ื”ื•ื ืฆืžื— ืคื•ืจื— ืฉืžืงื•ืจื• ื‘ืฆืคื•ืŸ ืืžืจื™ืงื”. ื”ื•ื ืขืฉื•ื™ ืœื”ืงืœ ืขืœ ืžืกืคืจ ืชืกืžื™ื ื™ื ืฉืœ ื’ื™ืœ ื”ืžืขื‘ืจ, ื›ื•ืœืœ ื’ืœื™ ื—ื•ื, ื—ืจื“ื”, ื“ื™ื›ืื•ืŸ ื•ื”ืคืจืขื•ืช ื‘ืชืคืงื•ื“ ืžื™ื ื™.

ื ื™ืกื•ื™ ืืงืจืื™ ื•ืžื‘ื•ืงืจ ื‘ื”ืฉืชืชืคื•ืช ื ืฉื™ื ื‘ืฉืœื‘ื™ื ื”ืžื•ืงื“ืžื™ื ืฉืœ ื—ื™ื“ืœื•ืŸ ื•ืกืช ืžืฆื ื›ื™ ื ื˜ื™ืœืช 6.5 ืžื™ืœื™ื’ืจืžื™ื ืฉืœ ืชืžืฆื™ืช ืฉื•ืจืฉ ืงื•ื”ื•ืฉ ืฉื—ื•ืจ ืžื“ื™ ื™ื•ื ื‘ืžืฉืš ืฉืžื•ื ื” ืฉื‘ื•ืขื•ืช ื”ื‘ื™ืื” ืœืฉื™ืคื•ืจ ืžืฉืžืขื•ืชื™ ื‘ืชืกืžื™ื ื™ ื’ื™ืœ ื”ืžืขื‘ืจ, ื‘ื”ืฉื•ื•ืื” ืœืงื‘ื•ืฆืช ื”ื‘ื™ืงื•ืจืช, ื•ืœื ื“ื•ื•ื—ื• ืชื•ืคืขื•ืช ืœื•ื•ืื™.27 ืžื—ืงืจ ื ื•ืกืฃ ื‘ืงืจื‘ ื ืฉื™ื ืœืื—ืจ ื—ื™ื“ืœื•ืŸ ื•ืกืช ืขื ื’ืœื™ ื—ื•ื ืžืฆื ืฉืงื•ื”ื•ืฉ ืฉื—ื•ืจ ื”ื‘ื™ื ืœื™ืจื™ื“ื” ื‘ืžืกืคืจ ื’ืœื™ ื”ื—ื•ื ื•ื‘ื—ื•ืžืจืชื, ืฉื™ืคืจ ืืช ืื™ื›ื•ืช ื”ื—ื™ื™ื ื•ื”ื™ื” ื™ืขื™ืœ ื•ืชืจ ืžืฉืžืŸ ื ืจ ื”ืœื™ืœื”, ืชื•ืกืฃ ืื—ืจ ืฉื‘ื• ืžืฉืชืžืฉื™ื ืœืขื™ืชื™ื ืงืจื•ื‘ื•ืช ืขื‘ื•ืจ ื’ื™ืœ ื”ืžืขื‘ืจ.28 

ื”ืื™ื’ื•ื“ ื”ืกืคืจื“ื™ ืœื’ื™ืœ ื”ืžืขื‘ืจ ื”ื’ื™ืข ืœืžืกืงื ื” ื›ื™ "ืงื•ื”ื•ืฉ ืฉื—ื•ืจ ื”ื•ื ืื•ืคืฆื™ื” ื˜ื™ืคื•ืœื™ืช ื‘ื˜ื•ื—ื” ื•ื™ืขื™ืœื” ืœื”ืงืœื” ืขืœ ืชืกืžื™ื ื™ื ื•ื–ื•ืžื•ื˜ื•ืจื™ื™ื."29 

ื ื™ืชืŸ ืœืงื—ืช ืงื•ื”ื•ืฉ ืฉื—ื•ืจ ื‘ืฆื•ืจืช ื›ืžื•ืกื•ืช, ืชืžืฆื™ืช ืื• ื—ืœื™ื˜ื”. ืงื™ื™ืžื™ื ื’ื ืฉื™ืœื•ื‘ื™ื ืฉืœ ืงื•ื”ื•ืฉ ืฉื—ื•ืจ ืขื ืžืจื›ื™ื‘ื™ื ืื—ืจื™ื, ื›ืžื• ืชืœืชืŸ ืื“ื•ื, ืคืจืข ืื• ืื™ื–ื•ืคืœื‘ื•ื ื™ื ืžืกื•ื™ื”. ื”ืžื™ื ื•ืŸ ื”ืžืงื•ื‘ืœ ืœื”ืงืœื” ืžืฉืžืขื•ืชื™ืช ืขืœ ื’ืœื™ ื—ื•ื ื”ื•ื 40 ืžื™ืœื™ื’ืจื ื‘ื™ื•ื.

ื”ืฉื•ืจื” ื”ืชื—ืชื•ื ื”

ืจื•ื‘ ื”ื ืฉื™ื ืกื•ื‘ืœื•ืช ืžืชืกืžื™ื ื™ื ืฉื ื’ืจืžื™ื ืขืœ-ื™ื“ื™ ื”ืฉื™ื ื•ื™ื™ื ื”ื”ื•ืจืžื•ื ืœื™ื™ื ื”ืžืชืจื—ืฉื™ื ื‘ื’ื™ืœ ื”ืžืขื‘ืจ. ื ื˜ื™ืœืช ืชื•ืกืคื™ื ืชื•ืžื›ื™ื ื‘ืชืงื•ืคืช ื”ืžืขื‘ืจ ื”ื–ื• ื™ื›ื•ืœื” ืœืขื–ื•ืจ ืœืš ืœื”ืจื’ื™ืฉ ื˜ื•ื‘ ื™ื•ืชืจ, ืœื”ืงืœ ืขืœ ื”ืชืกืžื™ื ื™ื ื•ืœืฉืžื•ืจ ืขืœ ืขืฆืžื•ืช ื—ื–ืงื•ืช ื•ื’ื•ืฃ ื‘ืจื™ื. 

ืืžื ื ืืคืฉืจ ืœืงื—ืช ืชื•ืกืคื™ื ื ืคืจื“ื™ื, ื›ืžื• ืกื™ื“ืŸ, ื•ื™ื˜ืžื™ืŸ D, ืžื’ื ื–ื™ื•ื, ืžืืงื”, ืžืœื˜ื•ื ื™ืŸ ื•ืงื•ื”ื•ืฉ ืฉื—ื•ืจ, ืื‘ืœ ืชื•ืกืคื™ื ืจื‘ื™ื ืฉืžื™ื•ืขื“ื™ื ื‘ืžื™ื•ื—ื“ ืœื’ื™ืœ ื”ืžืขื‘ืจ ืžื›ื™ืœื™ื ืฉื™ืœื•ื‘ื™ื ืฉืœ ืžืจื›ื™ื‘ื™ื ืขื ื”ืฉืคืขื” ืกื™ื ืจื’ื˜ื™ืช ืœื”ืงืœื” ืขืœ ืชืกืžื™ื ื™ ื’ื™ืœ ื”ืžืขื‘ืจ. ื™ืฉ ืžื’ื•ื•ืŸ ืชื›ืฉื™ืจื™ื ืœื’ื™ืœ ื”ืžืขื‘ืจ, ืžืชื•ืกืคื™ื ืฉื ื•ืขื“ื• ืœื”ืงืœ ืขืœ ื’ืœื™ ื—ื•ื, ื“ืจืš ืชื•ืกืคื™ื ืœืฉื™ืคื•ืจ ื”ืฉื™ื ื” ื•ืขื“ ืžื•ืœื˜ื™-ื•ื™ื˜ืžื™ื ื™ื ืœื’ื™ืœ ื”ืžืขื‘ืจ ืขื ื•ื™ื˜ืžื™ื ื™ื ื•ืžื™ื ืจืœื™ื ืžืจื•ื‘ื™ื ืฉืžื›ื™ืœื™ื ืื™ื–ื•ืคืœื‘ื•ื ื™ื ืžืกื•ื™ื”. ื—ืคืฉื™ ืชื•ืกืฃ ืฉืžื›ื™ืœ ืืช ื”ืžืจื›ื™ื‘ื™ื ื”ืขื™ืงืจื™ื™ื ื”ืžืชื•ืืจื™ื ืœืžืขืœื”, ืœืชืžื™ื›ื” ื‘ื‘ืจื™ืื•ืช ื•ื‘ืจื•ื•ื—ื” ื”ื›ืœืœื™ืช ืฉืœืš. 

ืชืžื™ื“ ื›ื“ืื™ ืœื”ืชื™ื™ืขืฅ ืขื ื”ืจื•ืคื ื”ืžื˜ืคืœ ืื• ืขื ืชื–ื•ื ืื™ ืžื•ืกืžืš ืœืคื ื™ ืชื—ื™ืœืช ื ื˜ื™ืœื” ืฉืœ ืชื•ืกืคื™ื ื—ื“ืฉื™ื ืœื’ื™ืœ ื”ืžืขื‘ืจ, ื›ื“ื™ ืœื•ื•ื“ื ืฉื”ืชื•ืกืคื™ื ืžืชืื™ืžื™ื ืขื‘ื•ืจืš ื•ืœื ืชื”ื™ื” ืื™ื ื˜ืจืืงืฆื™ื” ื‘ื™ื ื ืœื‘ื™ืŸ ื”ืชืจื•ืคื•ืช ืฉืืช ืื•ืœื™ ื ื•ื˜ืœืช. 

ื”ืคื ื™ื•ืช:

  1. Introduction - Menopausal Symptoms: Comparative Effectiveness of Therapies - NCBI Bookshelf. Accessed April 21, 2024. 
  2. Education - National Menopause Foundation. Accessed April 21, 2024. 
  3. National Menopause Foundation Menopause Symptom Checklist - National Menopause Foundation. Accessed April 21, 2024. 
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  6. Ryczkowska K, Adach W, Janikowski K, Banach M, Bielecka-Dabrowa A. Menopause and womenโ€™s cardiovascular health: is it really an obvious relationship? Arch Med Sci. 2023;19(2):458. 
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  8. Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161. 
  9. Tarleton EK, Littenberg B. Magnesium intake and depression in adults. J Am Board Fam Med. 2015;28(2):249-256. 
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  11. Castiglioni S, Cazzaniga A, Albisetti W, Maier JAM. Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions. Nutrients. 2013;5(8):3022. 
  12. Kaushal MJ, Magon N. Vitamin D in midlife: The sunrise vitamin in the sunset of life. J Midlife Health. 2012;3(2):97. 
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